André O'Reilly Beringhs

Ph.D. Graduate

U.S. Food and Drug Administration

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EDUCATION

2015-2021        Ph.D. in Pharmaceutical Sciences (Pharmaceutics) – University of Connecticut

2013-2015        M.Sc. in Pharmacy (Drugs & Pharmaceuticals) – Federal University of Santa Catarina, Brazil.

2009-2013        B.Sc. in Pharmacy and Biochemistry – Federal University of Santa Catarina, Brazil.

AWARDS/FELLOWSHIPS

2019                 University of Connecticut’s Provost for Academic Affairs recognition on Teaching Excellence for the 2018-2019 Academic Year, University of Connecticut.

2019                 Gerald J. Jackson Memorial Fellowship, University of Connecticut.

2018                 Research Award Travelship sponsored by AstraZeneca for the 2018 AAPS PharmSci 360 Meeting, Washington DC, USA.

2018                 Best Abstract Award at the 2018 AAPS PharmSci 360 Meeting, Washington DC, USA.

2018                 Poster Award at the 1st UConn-URI/AAPS Joint Symposium, Storrs CT, USA.

2018                 First Place AAPS-NERDG Academic Research Award, Farmington CT, USA.

2017                 Abstract Award. 2nd Joint Scientific Symposium “Moving Towards the Future of Medicine” AAPS/SAPA-CT, University of Connecticut, Storrs CT, USA.

PUBLICATIONS

SONG, D.*; BERINGHS, A.O.*; JOSHI, G.; TRAN, T.H.; CLAFFEY, K.; YUAN, H.; ZHUANG, Z.W.; LU, X. Overcoming hypoxia-induced chemoresistance to cisplatin through tumor oxygenation monitored by optical imaging. Nanotheranostics, v. 3 (2), p. 223-235, 2019. DOI: 10.7150/ntno.35935. *Equal contributors.

GLASS, S.; GONZALEZ-FAJARDO, L.; BERINGHS, A.O.; LU, X. Redox Potential and ROS-Mediated Nanomedicines for Improving Cancer Therapy. Antioxidants and Redox Signaling, v. 30 (5), p. 747-761, 2019. DOI: 10.1089/ars.2017.7370

LAKHSMANAN, R.; CAMPBELL, J.; UKANI, G.; BERINGHS, A.O.; SELVARAJU, V.; THIRUNAVUKKARASU, M.; LU, X.; PALESTY, J.A.; MAULIK, N. Evaluation of Dermal Tissue Regeneration Using Resveratrol Loaded Fibrous Matrix in a Preclinical Mouse Model of Full-Thickness Ischemic Wound. International Journal of Pharmaceutics, v. 558, p. 177-186, 2019. DOI: 10.1016/j.ijpharm.2019.01.001

ESPÍNDOLA, B.; BERINGHS, A.O.; SONAGLIO, D.; STULZER, H.K.; SILVA, M.A.S.; FERRAZ, H.G.; PEZZINI, B.R. Liquisolid Pellets: A Pharmaceutical Technology Strategy to Improve the Dissolution Rate of Ritonavir. Saudi Pharmaceutical Journal, v. 27(5), p. 702-712, 2019. DOI: 10.1016/j.jsps.2019.04.005

FRANÇA, M.T.; BERINGHS, A.O.; PEREIRA, R.N.; MARCOS, T.M.; BAZZO, G.C.; STULZER, H.K. The role of sodium alginate on the supersaturation state of the poorly soluble drug chlorthalidone. Carbohydrate Polymers, v. 209, p. 207-214, 2019. DOI: 10.1016/j.carbpol.2019.01.007

ANZILAGGO, D.; BERINGHS, A.O.; PEZZINI, B.R.; SONAGLIO, D.; STULZER, H.K. Liquisolid Systems: Understanding the impact of drug state (solution or dispersion), nonvolatile solvent and coating material on simvastatin apparent aqueous solubility and flowability. Colloids and Surfaces B: Biointerfaces, v. 175, p. 36-43, 2019. DOI: 10.1016/j.colsurfb.2018.11.044

CHEN, J.; DONG, Q.; HUANG, Y.; MA, X.; FAN, T-H.; BIAN, Z.; BERINGHS, A.O.; LU, X.; LEI, Y. Preparation, characterization and application of a protein hydrogel with rapid self-healing and unique autofluorescent multi-functionalities. Journal of Biomedical Materials Research Part A, v. 107, p. 81-91, 2019. DOI: 10.1002/jbm.a.36534

BERINGHS, A.O.; MINATOVICZ, B.C.; ZHANG, G.G.Z.; CHAUDHURI, B.; LU, X. Impact of Porous Excipients on the Manufacturability and Product Performance of Solid Self-Emulsifying Drug Delivery Systems. AAPS PharmSciTech, v. 19(7), p. 3298-3310, 2018. DOI: 10.1208/s12249-018-1178-x

BERINGHS, A.O.; FONSECA, A.B.S.; DE CAMPOS, A.M.; SONAGLIO, D. Association of PLGA Microspheres to Carrier Pellets by Fluid Bed Coating: A Novel Approach towards Improving the Flowability of Microparticles. Journal of Pharmaceutics, Article ID: 3874348, 2018. DOI: 10.1155/2018/3874348

NART, V.*; BERINGHS, A.O.*; FRANCA, M.T.; ESPÍNDOLA, B.; PEZZINI, B.R.; STULZER, H.K. Carnauba wax as a promising excipient in melt granulation targeting the preparation of mini-tablets for sustained release of highly soluble drugs. Materials Science & Engineering C: Biomimetic Materials, Sensors and Systems, v. 70, p. 250-257, 2017. *Equal contributors. DOI: 10.1016/j.msec.2016.07.070

DAL PIZZOL, C.; BERINGHS, A.O.; SILVA, E.W.; SONAGLIO, D.; DE CAMPOS, A.M.; CRECZYNSKI-PASA, T.B. Application of Response Surface Methodology for the Technological Improvement of Solid Lipid Nanoparticles. Journal of Nanoscience and Nanotechnology, v. 16, p. 1238-1247, 2016. DOI: 10.1166/jnn.2016.11669

PEZZINI, B.R.; BERINGHS, A.O.; FERRAZ, H.G.; SILVA, M.A.S.; STULZER, H.K.; SONAGLIO, D. Liquisolid technology applied to pellets: evaluation of the feasibility and dissolution performance using felodipine as a model drug. Chemical Engineering Research & Design, v. 110, p. 62-69, 2016. DOI: 10.1016/j.cherd.2016.01.037

BERINGHS, A.O.; DALMINA, M.; CRECZYNSKI-PASA, T.B.; SONAGLIO, D. Response Surface Methodology IV-Optimal design applied to the performance improvement of an RP-HPLC-UV method for the quantification of phenolic acids in Cecropia glaziovii products. Brazilian Journal of Pharmacognosy, v. 25, p. 513-521, 2015. DOI: 10.1016/j.bjp.2015.05.007

BERINGHS, A.O.; OLIVEIRA, P.R.; MURAKAMI, F.S.; CUFFINI, S.L.; DE CAMPOS, C.E.M.; SILVA, M.A.S.; CARDOSO, S.G.; SONAGLIO, D. Effects of Moisture and Fillers on the Processability and Solid-State Properties of Carbamazepine Pellets. Journal of Pharmaceutical Sciences and Pharmacology, v. 1, p. 264-274, 2014. DOI: 10.1166/jpsp.2014.1036

BERINGHS, A.O.; SOUZA, F.M.; CAMPOS, A.M.; FERRAZ, H.G.; SONAGLIO, D. Technological development of Cecropia glaziovi Snetl. extract pellets by extrusion-spheronization. Brazilian Journal of Pharmacognosy, v. 23, p. 160-168, 2013. DOI: 10.1590/S0102-695X2012005000123

BERINGHS, A.O.; ROSA, J.M.; STULZER, H.K.; BUDAL, R.M.; SONAGLIO, D. Green clay and aloe vera peel-off facial masks: Response Surface Methodology applied to the formulation design. AAPS PharmSciTech, v. 14, p. 445-455, 2013. DOI: 10.1208/s12249-013-9930-8

SONAGLIO, D.; BERINGHS, A.O.; PORFÍRIO, A.; BATAILLE, B. On the factors influencing the extrusion strain, particle size and dissolution behavior of multiparticulate systems obtained by extrusion/spheronization. Powder Technology, v. 230, p. 54-62, 2012. DOI: 10.1016/j.powtec.2012.06.052

PATENTS

BERINGHS, A.O.; NDAYA, D.; KASI, R.M.; LU, X. Nanoparticles for Imaging and Therapy. U.S. Patent and Trademark Office. Provisional Patent Application No. 62/812,944. Filed: 03/01/2019.

BERINGHS, A.O.; VALDEZ, T.A.; LU, X. Sublingual and Buccal Administrations of Fluorescent Agents for Optical Imaging. U.S. Patent and Trademark Office. International Application Number PCT/US19/25067. Provisional Filed: 03/30/2018. PCT Filed: 03/30/2019.

PEZZINI, B.R.; TAMBOSI, G.; SOARES, L.; STULZER, H.K.; FERNANDES, D.; SONAGLIO, D.; BERINGHS, A.O.; SORDI, R. Solid dispersion, manufacturing process and applications. INPI No. BR1020160239907. Filed: 10/14/2016.

FERRAZ, H.G.; PEZZINI, B.R.; SONAGLIO, D.; SILVA, M.A.S.; BERINGHS, A.O.; ESPÍNDOLA, B.; STULZER, H.K. Liquisolid multiparticulate systems for oral administration, manufacturing process and applications. INPI No. BR1020160155533. Filed: 07/01/2016